The FELIX laboratory at Radboud University in Nijmegen, the Netherlands, is an infrared free electron laser facility with a unique laboratory dedicated to molecular structure identification using novel experimental methodologies combining infrared spectroscopy and mass spectrometry.

In the context of the Charlie project, the team at FELIX used these unique tools to identify novel diagnostic biomarkers for pyridoxine-dependent epilepsy (PDE). We also use mass spectrometry imaging (MSI) to obtain “molecular images” of metabolites in tissues from mouse models for PDE provided by CHARLIE consortium members (German Mouse Clinic and the Leavitt Lab).

In addition to the unique collection of infrared lasers, our lab operates as mass spectrometry facility for metabolomics screening and metabolite ID.

In the photo from right to left: Dr. Jonathan Martens (team leader) and Jelle Schuurman (PhD student).